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Publikācija: Solvates of Dasatinib: Diversity and Isostructurality

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Solvates of Dasatinib: Diversity and Isostructurality
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors I. Sarceviča
I. Grante
Sergejs Beļakovs
T. Rekis
K. Bērziņš
Andris Actiņš
Liāna Orola
Keywords hydrates/solvates, solvation, crystal structure, powder X-ray diffractometry
Abstract A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.
DOI: 10.1016/j.xphs.2016.01.024
Hyperlink: http://www.sciencedirect.com/science/article/pii/S0022354916003245 
Reference Sarceviča, I., Grante, I., Beļakovs, S., Rekis, T., Bērziņš, K., Actiņš, A., Orola, L. Solvates of Dasatinib: Diversity and Isostructurality. Journal of Pharmaceutical Sciences, 2016, Vol.105, Iss.4, pp.1489-1495. ISSN 0022-3549. Available from: doi:10.1016/j.xphs.2016.01.024
ID 23318