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Publikācija: Preparation and Characterization of Strontium Ranelate Loaded Microcapsules

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Preparation and Characterization of Strontium Ranelate Loaded Microcapsules
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Anastasija Smirnova
Dagnija Loča
Jānis Ločs
Keywords strontium ranelate, PLA, microcapsules, microspheres, drug delivery systems
Abstract Musculoskeletal disorders such as osteoporosis are becoming a great problem all over the world. Strontium ranelate (SrRan), a novel orally active agent consisting of two atoms of stable strontium and the organic moiety ranelic acid, has proven drug ability to increase not only the bone mass but also mechanical properties [1]. Despite the advantages it has been shown that systemic administration of SrRan can cause such side effects as diarrhea, hypersensitivity and myocardial infarction [2]. Microencapsulation of SrRan could be a novel way to avoid the possible side effects from the systemic drug use as well as to increase its efficiency by local delivery of drug right to the affected bone site. Thus in the current research an attempt was made to prepare and characterize poly(lactic acid)/srontium ranelate microcapsules.
Hyperlink: http://alephfiles.rtu.lv/TUA01/000057303_e.pdf#page=93 
Reference Smirnova, A., Loča, D., Ločs, J. Preparation and Characterization of Strontium Ranelate Loaded Microcapsules. In: The 25th International Baltic Conference of Engineering Materials & Tribology BALTMATTRIB 2016: Abstracts Book, Latvia, Riga, 3-4 November, 2016. Riga: The Latvian Materials Research Society, 2016, pp.93-93. ISBN 978-9934-19-029-2.
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