Conjugate Addition of Aryl Nucleophiles to α,β-Unsaturated Cinnamic Acid Derivatives Containing Evans Type Chiral Auxiliaries

Tetrahedron: Asymmetry 2016
Zigmārs Leitis, Viesturs Lūsis

Cinnamides containing oxazolidin-2-one type auxiliaries have been prepared. A novel pathway to chiral 4-aryl-6-methyl-3,4-dihydrocoumrines via the asymmetric conjugate addition of arylmagnesium bromides to these cinnamides is described.

Keywords
aryl nucleophiles, α,β-unsaturated cinnamic acid derivatives
DOI
10.1016/j.tetasy.2016.07.003
Hyperlink
http://www.sciencedirect.com/science/article/pii/S0957416616301586

Leitis, Z., Lūsis, V. Conjugate Addition of Aryl Nucleophiles to α,β-Unsaturated Cinnamic Acid Derivatives Containing Evans Type Chiral Auxiliaries. Tetrahedron: Asymmetry, 2016, Vol.27, Iss.17-18, pp.843-851. ISSN 0957-4166. Available from: doi:10.1016/j.tetasy.2016.07.003

Publication language
English (en)