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Publikācija: X-Ray Crystallography-Promoted Drug Design of Carbonic Anhydrase Inhibitors

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language X-Ray Crystallography-Promoted Drug Design of Carbonic Anhydrase Inhibitors
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Jekaterīna Ivanova
Raivis Žalubovskis
Muhammet Tanc
Andris Kazaks
Claudiu T. Supuran
Kaspars Tārs
Janis Leitans
Keywords
Abstract 1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications. This journal is
DOI: 10.1039/c5cc01854d
Hyperlink: http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC01854D#!divAbstract 
Reference Ivanova, J., Žalubovskis, R., Tanc, M., Kazaks, A., Supuran, C., Tārs, K., Leitans, J. X-Ray Crystallography-Promoted Drug Design of Carbonic Anhydrase Inhibitors. Chemical Communications, 2015, Vol.51, pp.7108-7111. ISSN 1359-7345. Available from: doi:10.1039/c5cc01854d
Additional information Citation count:
ID 24039