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Publikācija: Inhibitor Studies of ε-Trimethyllysine Hydroxylase by Means of NMR and Computer Modelling

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Inhibitor Studies of ε-Trimethyllysine Hydroxylase by Means of NMR and Computer Modelling
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Diāna Zeļencova
Edvards Liepiņš
Keywords ε-Trimethyllysine Hydroxylase (TMLH) Nuclear Magnetic Resonance (NMR)
Abstract ε-Trimethyllysine hydroxylase (TMLH) is a homodimer enzyme located in the submitochondrial matrix. TMLH is a ferrous iron and 2-ketoglutarate dependent oxygenase that catalyze the stereospecific oxidation of ε-trimethyllysine (TML) to β-hydroxy-TML (HTML) that is a first step in the L-carnitine biosynthesis pathway. The inhibition of the TMLH is proposed to have the similar and more potent effect on the energy metabolism processes than meldonium (clinically used anti-ischemia drug). Thus, it will become possible to reduce significantly the concentrations of the L-carnitine and to shift the energy metabolism from the β-oxidation of long-chain fatty acids to glycolysis.
Hyperlink: http://www.euromar2016.org/program.php 
Reference Zeļencova, D., Liepiņš, E. Inhibitor Studies of ε-Trimethyllysine Hydroxylase by Means of NMR and Computer Modelling. In: EUROMAR Denmark 2016: Book of Abstracts, Denmark, Aarhus, 3-7 July, 2016. Aarhus: 2016, pp.433-433.
Full-text
ID 24098