Amide Group Directed Protonolysis of Cyclopropane. En Route To 2,2-Disubstituted Pyrrolidines

Latvijas Universitātes 75.Starptautiskā konference. Ķīmijas sekcija: tēžu krājums 2017
Marija Skvorcova, Aigars Jirgensons

We have demonstrated that cyclopropanes with amide, carbamate or urea function can selectively direct the proton attack to cyclopropane C-C bond, while in the case of electron withdrawing amide the cleavage was unselective. We have explored substrate scope for the transformation of aminomethylcyclopropanes to pyrrolidines using carbamate function as a directing group.

Keywords
carbamate, protonolysis, cyclopropane, pyrrolidine

Skvorcova, M., Jirgensons, A. Amide Group Directed Protonolysis of Cyclopropane. En Route To 2,2-Disubstituted Pyrrolidines. In: Latvijas Universitātes 75.Starptautiskā konference. Ķīmijas sekcija: tēžu krājums, Latvia, Rīga, 10-10 February, 2017. Rīga: Latvijas Universitāte, 2017, pp.24-24. ISBN 978-9934-18-206-8.

Publication language
English (en)