Topological Functioning Model specifies functional and structural characteristics of a system in the holistic manner. Cause-and-effect relations link cause and effect functional characteristics of the system, illustrating causality in it. The Unified Modelling Language (UML) provides its own relationship kinds among elements. Traditionally, a use of UML relationships depends on analyst’s experience in UML and knowledge about the system. However, after TFM transformation meaning of cause-and-effect relations in UML model is not always clear. The paper summarizes research results on this matter and provides mapping guidelines from TFM causal relations to often used UML relationships. These guidelines can be applied in further (manual or automated) refinement of UML diagrams.