The implementation of comprehensive health information systems in the public healthcare sector is a complex issue plagued with many challenges. This is more evident in healthcare systems within low-medium income countries (LMICs) Most LMICs face a wide variety of health-related challenges, and healthcare systems in these countries are struggling with limited resources and capabilities to tackle some of the challenges. The use of Information and Communication Technology (ICT) could enable healthcare systems to achieve this. As such, Information Systems (IS) in the healthcare sector could provide relevant information to stakeholders to adequately deliver healthcare services to a population. This article aims to identify emerging trends in Health information Systems implementation in the healthcare sector with the goal of contributing towards an understanding on the nature, contributions, and potential of the on-going research on Health information systems implementation for facilitating healthcare service provision in resource constrained environments. In doing so, a range of databases including Google Scholar, EBSCOhost, IEEE Xplore, Proquest and many more were searched to identify review papers that related to the implementation of Information systems in organizational settings focusing on the healthcare sector.