Extensive research on hydroxyapatite and other calcium phosphates in the eld of biomaterials has been taking place for over 50 years. However, only in the last 10 years there has been wider understanding of the in uence of the structure of apatites on the biocompatibility of the material. Therefore, great attention is paid to the modi cation of existing materials, the creation of new materials and comprehensive characterization. Insu cient attention is still being paid to the convenient and e cient characterization of the structure and quality of nanosized calcium phosphates. With the development of spectroscopic analytical methods and IT technologies, it is possible to obtain more accurate data on synthesized material. For instance, Fourier Transform Infrared Spectroscopy (FTIR) techniques, which can provide not only qualitative, but also quantitative information about a sample in a very short time, combined with statistical methods, provide a convenient graphical and visual representation of the data. Although over the past 20 years the usage of statistical methods in the analysis of spectroscopic data has increased more than 10 times (number of article on the usage of statistical methods in FTIR spectroscopy indexed in SCOPUS database in 1996 was 20, but in 2016 it was 232), however, it has been unreasonably forgotten in studies of calcium phosphates. Possibly the lack of the quality of the spectra does not allow to use it. The results of the doctoral dissertation substantiate the high potential of data multi- factorial analysis in both calcium phosphate production and research process, as it allows more detailed analysis of the obtained data and prediction of physico-chemical properties of the material. In this work, an innovative FTIR cantilever-enhanced photoacoustic spectroscopy (PAS) method has been used, which was rst used in spectroscopic studies of both calcium phosphates and bacteria. Cantilever-enhanced photoacoustic detectors developed and patented by GASERA Ltd. are used to develop completely new analytical methods in a number of innovative EU-funded projects (such as IRON, HORIZON 2020 EU-PROJECT, and DOGGIE and CUSTUM).