The First Total Synthesis of Usabamycins a and C

Tetrahedron Letters 2017
Guna Sakaine, R. Zemribo, Gints Šmits

The first total synthesis of usabamycins A and C from inexpensive and readily available amino acids – homoalanine and glycine and featuring a stereoselective Ireland-Claisen rearrangement as well as a novel 7-membered ring formation reaction is described.

Keywords
Anti cancer agents | Ireland-Claisen rearrangement | Natural products | Pyrrolo[14]benzodiazepines | Usabamycin A | Usabamycin C
DOI
10.1016/j.tetlet.2017.05.020
Hyperlink
http://www.sciencedirect.com/science/article/pii/S0040403917305920?via%3Dihub

Sakaine, G., Zemribo, R., Šmits, G. The First Total Synthesis of Usabamycins a and C. Tetrahedron Letters, 2017, Vol.58, Iss.25, pp.2426-2428. ISSN 0040-4039. Available from: doi:10.1016/j.tetlet.2017.05.020

Publication language
English (en)