Design and Synthesis of 3,3,3-Trifluoroalanine Analogues as Potential Antibacterials

Balticum Organicum Syntheticum (BOS 2018): Program and Abstracts 2018
Konstantinos Grammatoglou, Laura Levy, Aigars Jirgensons

We screened small library of halogenated alanines against OASS and found that 3,3,3-trifluoroalanine acts as irreversible, although slow, inhibitor of this enzyme. Next, various analogues of 3,3,3-trfluoroalanine were targeted to improve the inhibitory potency.

Keywords
3,3,3-Trifluoroalanine, OASS, Antibacterials

Grammatoglou, K., Levy, L., Jirgensons, A. Design and Synthesis of 3,3,3-Trifluoroalanine Analogues as Potential Antibacterials. In: Balticum Organicum Syntheticum (BOS 2018): Program and Abstracts, Estonia, Tallinn, 1-4 July, 2018. Tallinn: 2018, pp.59-59.

Publication language
English (en)