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Publikācija: Cytokines as Therapeutic Agents and Targets in Heart Disease

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Research project
Defending: ,
Publication language English (en)
Title in original language Cytokines as Therapeutic Agents and Targets in Heart Disease
Field of research 2. Engineering and technology
Sub-field of research 2.6 Medical engineering
Authors Arita Dubņika
Martin A.C. Manoukian
M.Rezaa Mohammadi
Mansi Bharat Parekh
Abhijit Achyut Gurjarpadhye
Mohammed Inayathullah
Viktors Dubņiks
Jonathan R.T. Lakey
Jayakumar Rajadas
Keywords Cytokine therapies, Ischemia, Myocardial infarction, Therapeutic cytokines
Abstract Cytokine therapies have emerged during the past decade as promising noninvasive treatments for heart disease. In general, current drug treatments are directed towards symptom control and prevention of disease progression; however, many agents also produce cause side effects that alter quality of life. Cytokine based therapies have the potential to reduce post-infarct heart failure and chronic ischemia by stimulating the proliferation and differentiation of endothelial cells and bone marrow hematopoietic stem cells and mobilizing these cells toward ischemic tissue. In turn, these mobilized cell populations contribute to myocardial regeneration. In contrast, over-expression of several cytokines has been linked to a variety of heart diseases; thus, therapies targeting and monitoring these cytokines are of great interest. Here we summarize results from clinical studies on cytokines as therapeutic agents or therapeutic targets in the treatment for heart disease as well as cytokines involved in the evolution of heart disease.
DOI: 10.1016/j.cytogfr.2018.08.003
Hyperlink: https://www.sciencedirect.com/science/article/pii/S1359610118300820?via%3Dihub 
Reference Dubņika, A., Manoukian, M., Mohammadi, M., Bharat Parekh, M., Achyut Gurjarpadhye, A., Inayathullah, M., Dubņiks, V., Lakey, J., Rajadas, J. Cytokines as Therapeutic Agents and Targets in Heart Disease. Cytokine and Growth Factor Reviews, 2018, Vol.43, pp.54-68. ISSN 1359-6101. Available from: doi:10.1016/j.cytogfr.2018.08.003
Additional information Citation count:
ID 28139