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Publikācija: Development of Local Strontium Ranelate Delivery Systems and Long Term in Vitro Drug Release Studies in Osteogenic Medium

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Other research projects
Defending: ,
Publication language English (en)
Title in original language Development of Local Strontium Ranelate Delivery Systems and Long Term in Vitro Drug Release Studies in Osteogenic Medium
Field of research 3. Medical and Health sciences
Sub-field of research 3.1 Basic medicine including pharmacy
Authors Dagnija Loča
Anastasija Smirnova
Jānis Ločs
Arita Dubņika
Jana Vecstaudža
Līga Stīpniece
Elīna Makarova
Maija Dambrova
Keywords local drug delivery; strontium ranelate; osteoporosis; encapsulation; bone regeneration; osteogenic medium, calcium phosphate
Abstract It has been recognized that the operative stabilization of osteoporotic fractures should be followed up with an appropriate osteoporosis treatment in order to decrease the risk of repeated fractures. Despite the good clinical results of strontium ranelate (SrRan) towards the osteoporosis treatment, high drug doses and long treatment period cause an increased risk of serious side effects. Novel local SrRan/poly(lactic acid) (SrRan/PLA) delivery systems containing from 3.57 ± 0.28 wt% to 24.39 ± 0.91 wt% of active substance were developed. In order to resemble the naturally occurring processes, osteogenic media (OM) was used as a release medium for long term (121 days) in vitro drug release studies and UV/VIS method for the determination of SrRan content in OM was developed and validated. Biomimetic calcium phosphate precipitates were found on the surface and in the pores of prepared delivery system after microcapsule exposure to OM for 121 days as well as SrRan particles, indicating that the release of the drug have not been completed within 121 days. In vitro cell viability evaluation approved no cytotoxic effects of microcapsule suspensions and extracts.
DOI: 10.1038/s41598-018-35197-7
Hyperlink: https://www.nature.com/articles/s41598-018-35197-7 
Reference Loča, D., Smirnova, A., Ločs, J., Dubņika, A., Vecstaudža, J., Stīpniece, L., Makarova, E., Dambrova, M. Development of Local Strontium Ranelate Delivery Systems and Long Term in Vitro Drug Release Studies in Osteogenic Medium. Scientific Reports, 2018, Vol.8, pp.1-10. ISSN 2045-2322. Available from: doi:10.1038/s41598-018-35197-7
Additional information Citation count:
  • Scopus  0
ID 28357