Synthesis and Evaluation of the Antibacterial, Antioxidant Activities of Novel Functionalized Thiazole and Bis(Thiazol-5-Yl)Methane Derivatives
Arkivoc
2018
I. Parasotas,
K. Anusevicius,
R. Vaickelioniene,
I. Jonuskiene,
M. Stasevych,
V. Zvarych,
K.-P. Olena,
V. Novikov,
Sergejs Beļakovs,
V. Mickevicius
Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4-
hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding α-halocarbonyl
compounds in good yields. A series of chemical transformations of the obtained products were carried out,
and new functionalized thiazole derivatives with aliphatic, aromatic and heterocyclic substituents were
synthesized. 4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles were used as precursors
for the synthesis of bis(thiazol-5-yl)methane derivatives, which then were screened for their antibacterial,
antioxidant activities.
Keywords
antibacterial, antioxidant activities, thiazole, bis(thiazol-5-yl)methane derivatives
DOI
10.24820/ark.5550190.p010.159
Hyperlink
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.159
Parasotas, I., Anusevicius, K., Vaickelioniene, R., Jonuskiene, I., Stasevych, M., Zvarych, V., Olena, K., Novikov, V., Beļakovs, S., Mickevicius, V. Synthesis and Evaluation of the Antibacterial, Antioxidant Activities of Novel Functionalized Thiazole and Bis(Thiazol-5-Yl)Methane Derivatives. Arkivoc, 2018, Vol.2018, Part III, pp.240-256. ISSN 1551-7004. e-ISSN 1551-7012. Available from: doi:10.24820/ark.5550190.p010.159
Publication language
English (en)