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Publikācija: 2

Publication Type Conference paper
Funding for basic activity Research project
Defending: ,
Publication language English (en)
Title in original language 2,4-Diazidoquinazoline as Useful Starting Material in Heterocyclic Chemistry
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Ērika Bizdēna
Svetlana M. Goliškina
Armands Sebris
Anatoly Mishnev
Māris Turks
Keywords 2,4-Diazidoquinazoline, quinazoline, CuAAC, azido-tetrazolo tautomerism
Abstract It was discovered that 2,4-diazidoquinazoline in solution exists in a tautomeric equilibrium. The tetrazole – azide tautomerism of azidoquinazolines was studied since 1960s, however, its application for 2,4-derivatization of quinazolines is underexplored. For the first time the molecular structure of 5-(piperidin-1-yl)tetrazolo[1,5-a]quinazoline was proved by X-ray diffraction analysis. We have also shown that obtained 5-amino derivatives undergo CuAAC reaction with terminal alkynes to give novel quinazoline derivatives.
Reference Bizdēna, Ē., Goliškina, S., Sebris, A., Mishnev, A., Turks, M. 2,4-Diazidoquinazoline as Useful Starting Material in Heterocyclic Chemistry. In: XXII International Conference on Organic Synthesis: Scientific Program & Abstract Book, Italy, Florence, 16-21 September, 2018. Florence: 2018, pp.P271-P271.
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ID 28503