Synthesis of Phenylthiopurine Derivatives

Latvijas Universitātes 77. zinātniskā konference, ķīmijas sekcija: tēžu krājums 2019
Andris Jeminejs, Ērika Bizdēna

Purine derivatives are widely studied due to their biological activity and extensive potential in medicine. Thiopurine based compounds have already been proven as effective tools in the treatment of cancer and autoimmune disorders. A new synthetic approach for the synthesis of 6-azido-2-arylthiopurine derivatives 2 was developed. Further CuAAC reaction leaded to 6‑triazolyl-derivatives 3 with excellent yields. Additionally, by rearranging the synthetic approach regioisomers 6 were obtained.

Keywords
Purine, thiopurine, thiophenols, nucleophilic substitution, click reaction

Jeminejs, A., Bizdēna, Ē. Synthesis of Phenylthiopurine Derivatives. In: Latvijas Universitātes 77. zinātniskā konference, ķīmijas sekcija: tēžu krājums, Latvia, Rīga, 19-19 February, 2019. Rīga: 2019, pp.44-44.

Publication language
English (en)