Lipid-like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines - Contribution of Molecular Structure to Self-Assembling and Biological Properties

33rd Conference of the European Colloid and Interface Society: Book of Abstracts 2019
Martins Rucins, Māra Plotniece, Pavels Dimitrijevs, Ilona Domracheva, Krisjanis Smits, Dace Tirzīte, Kārlis Pajuste, Arkadij Sobolev, Aiva Plotniece

Design of nanoparticle delivery materials possessing biological activity is an ideal strategy for therapies. Cationic 1,4-dihydropyridines (1,4-DHP) capable of transfecting pDNA into cells were developed and demonstrated high transfection efficiencies.Eleven 4-(N-alkylpyridinium)-1,4-DHPs containing/noncontaining propargyl moiety/ies were synthesized. Increasing of alkyl chain lenght at N-atom of 4-(N-alkylpyridinium)-1,4-DHP ring or introduction propargyl moiety/ moieties in 1,4-DHP molecule influences cytotoxicity. Values of Z-averege diameter, polydispersity index and stability of nanoparticles of 4-(N-alkylpyridinium)-1,4-DHPs were determined by DLS.

Keywords
cationic 1,4-HHP, propargyl moiety, cytotoxicity, nanoparticles

Rucins, M., Plotniece, M., Dimitrijevs, P., Domracheva, I., Smits, K., Tirzīte, D., Pajuste, K., Sobolev, A., Plotniece, A. Lipid-like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines - Contribution of Molecular Structure to Self-Assembling and Biological Properties. In: 33rd Conference of the European Colloid and Interface Society: Book of Abstracts, Belgium, Leuven, 8-13 September, 2019. Leuven: KU Leuven, 2019, pp.245-245.

Publication language
English (en)