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Publikācija: Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Research project
Defending: ,
Publication language English (en)
Title in original language Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Research platform Materials, Processes, and Technologies
Authors Ingus Skadiņš
Juta Kroiča
Ilze Šalma
Aigars Reinis
Marina Putniņa
Dagnija Rostoka
Keywords impregnated biomaterials, interleukin-10, P. aeruginosa, S. epidermidis, TNF-α, β-defensin-2
Abstract Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In this in vitro study, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa was studied by evaluating the expression of inflammatory cytokines (Interleukin-10 (IL-10), -defensin-2 and tumour necrosis factor alpha (TNF- )) in tissue surrounding implanted biomaterials in vivo. The results of this study demonstrated that hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers had a prolonged antibacterial effect in comparison to biomaterials without biodegradable polymers. Surrounding tissue displayed higher levels of inflammatory cytokines when implanted biomaterials had not been previously impregnated with antibiotics.
DOI: 10.2478/prolas-2019-0028
Hyperlink: https://content.sciendo.com/view/journals/prolas/73/2/article-p177.xml 
Reference Skadiņš, I., Kroiča, J., Šalma, I., Reinis, A., Putniņa, M., Rostoka, D. Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines. Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact, and Applied Sciences, 2019, Vol. 73, No. 2, pp.177-184. ISSN 1407-009X. Available from: doi:10.2478/prolas-2019-0028
Additional information Citation count:
  • Scopus  0
ID 30150