Physical-Chemical Characterisation of Chitosan-Coated Liposomes as Putative Delivery Systems

1st Meeting COST Action CA18132 “Functional Glyconanomaterials for the Development of Diagnostics and Targeted Therapeutic Probes (GLYCOnanoPROBES)”: Book of Abstracts 2019
Kārlis Pajuste, Pavels Dimitrijevs, Martins Rucins, Nadya Pikun, Māra Plotniece, Anda Sipola, Arkadij Sobolev, Aiva Plotniece

Decoration of liposomes with chitosan is one of the approaches for the enhancement of their physical-chemical and biochemical properties. Chitosan is an attractive compound for the preparation of nanoaggregates due to the desirable properties like boiavailability, non-toxicity, biodegradability and stability. In this work we designed water soluble chitosan derivatives; prepared liposomes from the composition phospholipids and our original synthetic lipid-like compound, coated the obtained liposomes with chitosan derivative and studied stability and size distribution of chitosan coated liposomes for further development of these liposomes for biological application.

Keywords
chitosan, liposomes, delivery systems

Pajuste, K., Dimitrijevs, P., Rucins, M., Pikun, N., Plotniece, M., Sipola, A., Sobolev, A., Plotniece, A. Physical-Chemical Characterisation of Chitosan-Coated Liposomes as Putative Delivery Systems. In: 1st Meeting COST Action CA18132 “Functional Glyconanomaterials for the Development of Diagnostics and Targeted Therapeutic Probes (GLYCOnanoPROBES)”: Book of Abstracts, Portugal, Caparica, 18-20 November, 2019. Lisbon: NOVA University Lisbon, 2019, pp.58-58.

Publication language
English (en)