Data for the Synthesis and Characterisation of 2,6-Di(Bromomethyl)-3,5-Bis(Alkoxycarbonyl)-4-Aryl-1,4-Dihydropyridines as Important Intermediates for Synthesis of Amphiphilic 1,4-Dihydropyridines
Data in Brief 2020
Martins Rucins, Klāvs Pajuste, Arkadij Sobolev, Māra Plotniece, Nadiia Pikun, Kārlis Pajuste, Aiva Plotniece

This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)- 4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised. The 2,6-di(bromomethyl)-1,4-dihydropyridines are mainly used as intermediates for synthesis of various lipid-like compounds based on 1,4-dihydropyridine cycle. All the structures of 2,6- di(bromomethyl)-1,4-dihydropyridines were confirmed by Nuclear Magnetic Resonance (NMR, including 1H NMR and 13C NMR) data. Synthesis of other three 2,6-di(bromomethyl)- 3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines and their characterisation are reported herein at the first time. Information provided in this data file can be used in organic synthesis by other chemists to develop synthetic strategies for the construction of various cationic 1,4-dihydropyridine derivatives and related heterocycles.


Keywords
Azines, 1,4-dihydropyridines 2,6-di(bromomethyl)-1,4-dihydropyridines, bromination, NMR data
DOI
10.1016/j.dib.2020.105532
Hyperlink
https://www.sciencedirect.com/science/article/pii/S2352340920304261?via%3Dihub

Rucins, M., Pajuste, K., Sobolev, A., Plotniece, M., Pikun, N., Pajuste, K., Plotniece, A. Data for the Synthesis and Characterisation Of 2,6-Di(Bromomethyl)-3,5-Bis(Alkoxycarbonyl)-4-Aryl-1,4-Dihydropyridines as Important Intermediates for Synthesis of Amphiphilic 1,4-Dihydropyridines. Data in Brief, 2020, Vol. 30, Article number 105532. ISSN 2352-3409. Available from: doi:10.1016/j.dib.2020.105532

Publication language
English (en)
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