Technology Development for Betulin Integration into Nanofibers Web
5th International Conference on Natural Fibers: Materials of the Future (ICNF 2021): Proceedings 2021
Laimdota Vilcēna, Silvija Kukle, Zane Zelča

Preparations containing birch bark extract Betulin are used in medicine and cosmetics for skin care and treatment, whereas this biologically active compound is known to restore skin cells. At the same time, studies have shown that application of this compound as potential therapeutic agent is limited by its low bioavailability, high hydrophobicity, and insufficient intracellular accumulation. The use of nano-scale technologies could improve effectiveness of treatment with betulin (BE) -containing medicinal products in cosmetic/medical devices. In the experiment analysed betulin powder was used as biological active substance integrating it into the nanofibers web. During the preparation of spinning solution, the betulin powder was dissolved with ethanol (ET) then the resulting solution was combined with the 10 wt% polyvinyl alcohol (PVA) solution creating three types of spinning solutions with different betulin concentrations. Corresponding nanofibers webs obtained by using Nanospider type electrical electrospinning device.


Keywords
electrospininng, nanofibers, nanofibers web, betulin, bioactive components, polyvinyl alcohol matrix

Vilcēna, L., Kukle, S., Zelča, Z. Technology Development for Betulin Integration into Nanofibers Web. In: 5th International Conference on Natural Fibers: Materials of the Future (ICNF 2021): Proceedings, Portugal, Madeira (Online), 17-19 May, 2021. Braga: Sciencentris, 2021, pp.41-42. ISBN 978-989-54808-5-2.

Publication language
English (en)
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