The role of universities in shaping the future of society cannot be underestimated, as current students could become the potential leaders of tomorrow. Therefore, universities should serve as a basis for preparing future socio-ecological skills and values essential for a sustainable living, by reorienting current unsustainable ways of thinking and doing. This paper discusses the critical role that the Change Project Approach plays in creating the social transformation processes and actions required to reach the ambitions of the Sustainable Development Goals, enabling sustainable development in interdisciplinary university teaching. The Change Project Approach intervention has been highlighted in the university cases from the Baltic Sea region that have demonstrated important efforts to reorient university curricula. Through the Education for Sustainable Development course for teachers of Baltic University Programme, the purpose of the intervention is to stimulate the integration of sustainability education approaches into university teaching and learning. It demonstrates how sustainability competences may be acquired through learning initiatives, feasible to replicate within and across university departments and university institutions.