Synthesis of 1,2-Dihydroisoquinoline-1-Carboxylates under Cobalt Catalysis

Chemistry of Heterocyclic Compounds 2021
P.A Zagorska, Liene Grigorjeva, Jekaterina Boļšakova

[Figure not available: see fulltext.] A study of cobalt-catalyzed C–H functionalization of phenylglycine derivatives with alkynes is described. During the optimization studies, a range of cobalt catalysts, oxidants, base additives, and reaction solvents were evaluated. Product yield dependence on phenylglycine ester substituent was evaluated. Conditions for 1,2-dihydroisoquinoline synthesis with acceptable yield were found.

Keywords
1,2-dihydroisoquinoline | alkaloids | heterocycles | isoquinoline | phenylglycine
DOI
10.1007/s10593-021-02888-5
Hyperlink
https://link.springer.com/article/10.1007%2Fs10593-021-02888-5

Zagorska, P., Grigorjeva, L., Boļšakova, J. Synthesis of 1,2-Dihydroisoquinoline-1-Carboxylates under Cobalt Catalysis. Chemistry of Heterocyclic Compounds, 2021, Vol. 57, No. 2, pp.159-165. ISSN 0009-3122. Available from: doi:10.1007/s10593-021-02888-5

Publication language
English (en)