Visible Light-Mediated Synthesis of Se−S Bond-Containing Peptides

Advanced Synthesis and Catalysis 2021
Sindija Lapčinska, P Dmitrijevs, P Arsenyan

A visible light-initiated method has been developed for preparation of Se−S bond-containing peptides. The method is based on generation of sulfur-centered radical employing organic dye. The protocol is tolerant to unprotected peptides with “sensitive” amino acids. The stability of Se−S bond is evaluated in buffers at different pH (3.0–10.0) and also in the presence of oxidants and reducing agents. Additionally, the ability of Se−S bond to serve as an oxidation sensitive linker in biocompatible materials has been confirmed. (Figure presented.).

Keywords
glutathione | peptide | photocatalysis | selenocysteine
DOI
10.1002/adsc.202100751
Hyperlink
https://onlinelibrary.wiley.com/doi/10.1002/adsc.202100751

Lapčinska, S., Dmitrijevs, P., Arsenyan, P. Visible Light-Mediated Synthesis of Se−S Bond-Containing Peptides. Advanced Synthesis and Catalysis, 2021, Vol. 363, No. 16, pp.3968-3972. ISSN 1615-4150. e-ISSN 1615-4169. Available from: doi:10.1002/adsc.202100751

Publication language
English (en)