Modification of Cysteine and Selenocystine-containing Peptides by Electrophilic Cyclization and Visible Light-induced Reactions

2022
Sindija Lapčinska

Defending
17.02.2022. 14:00, Rīgas Tehniskā universitāte, Materiālzinātnes un lietišķās ķīmijas fakultāte, Rīga, Paula Valdena iela 3, 272. auditorija

Supervisor
Pavels Arsenjans

Reviewers
Māris Turks, Aigars Jirgensons, Edgars Sūna

The Doctoral Thesis has been prepared as a collection of thematically related scientificpublications that includes six scientific publications. Simple and efficient methods for functionalization of cysteine and selenocystine-containing peptides were established based on the generation of sulfenyl or selenyl electrophile. The electrophilic species were subsequently used in 5- and 6-endo-dig cyclization reactions yielding (hetero)cyclic systems. Novel atom-economic methods were developed for modification of selenocystine-containing peptides under visible light irradiation.

Keywords
Cisteīns, elektrofīls, redzamā gaisma, selēncistīns
DOI
10.7250/9789934227288

Lapčinska, Sindija. Modification of Cysteine and Selenocystine-containing Peptides by Electrophilic Cyclization and Visible Light-induced Reactions. PhD Thesis. Rīga: [RTU], 2022. 155 p.

Publication language
Latvian (lv)