Two-hemisphere model driven (2HMD) approach assumes modeling and use of procedural and conceptual knowledge on equal and related basis according to the principles of Model Driven Architecture (MDA), which separates different aspects of system modeling. This differentiates 2HMD approach from pure procedural, pure conceptual, and object oriented approaches. The approach may be applied in the context of modeling of a particular business domain as well as in the context of modeling the knowledge about the domain. Therefore, the principles of MDA via 2HMD approach may be applied not only in the context of software development but also in the context of the study course and program development. Knowledge modeling by 2HMD approach gives an opportunity to transparently analyze and compare knowledge to be provided and knowledge actually provided by courses belonging to a particular study program, and, thus, to identify and fill gaps between desirable and actual knowledge content of the study program.