Silver- and/or Titanium-Doped β-Tricalcium Phosphate Bioceramic with Antibacterial Activity against Staphylococcus Aureus

Ceramics International 2022
Līga Stīpniece, Ingus Skadiņš, Marika Ščeglova

Ag- and/or Ti-doped apatitic-tricalcium phosphate powders were synthesized by wet chemical precipitation method. Regardless of the element composition, calcination of the Ag- and/or Ti-doped apatitic tricalcium phosphate powders at 900 °C gave phase-pure β-tricalcium phosphate. Cumulative release of Ca(II) and Ag(I) ions in TRIS-HCl buffer solution was determined. Increase of the solubility of the β-tricalcium phosphate was observed with the addition of Ti. Furthermore, prolonged (up to 28 days) release of the Ag(I) ions from the Ag-doped and the Ag- and Ti-co-doped β-tricalcium phosphate was observed. Minimum inhibitory concentration and antibacterial activity of the Ag- and/or Ti-doped β-tricalcium phosphate powders against Gram-positive Staphylococcus aureus was determined. It was observed that the addition of both, Ti and Ag, confers antibacterial properties of the β-tricalcium phosphate against Staphylococcus aureus.

Keywords
Ag-/Ti-doping, β-tricalcium phosphate, Bioceramics, Antibacterial properties
DOI
10.1016/j.ceramint.2021.12.232
Hyperlink
https://www.sciencedirect.com/science/article/pii/S0272884221040268?via%3Dihub

Stīpniece, L., Skadiņš, I., Mosina, M. Silver- and/or Titanium-Doped β-Tricalcium Phosphate Bioceramic with Antibacterial Activity against Staphylococcus Aureus. Ceramics International, 2022, Vol. 48, No. 7, pp.10195-10201. ISSN 0272-8842. Available from: doi:10.1016/j.ceramint.2021.12.232

Publication language
English (en)