Ca2Fe2O5 Powder Antifungal Activity to the Candida Utilis Culture upon its Growth

BioMetals 2022
Svetlana Vihodceva, Vasily Bankovskis, Olga Muter, Andris Šutka

This study reports the impact of Ca2Fe2O5 porous powder on the yeast Candida utilis—as a fungal model—at different phases of growth, i.e., early exponential (6 h), mid-log (11 h), and stationary (17 h) phases. Ca2Fe2O5 inhibited the cell growth in a time-dependent manner. After 120 min incubation, the fungicidal activity of porous powder was observed, i.e., log reduction of 2.81 and 2.58 for 11 and 17 h cultures, respectively, reaching the maximum of 4 log reduction after 7 days. Nevertheless, the 6 h culture of C. utilis showed enhanced resistance to Ca2Fe2O5 with a ≤ 0.4 log reduction during the 7 days exposure. Our results not only showed that Ca2Fe2O5 has the potential to effectively eliminate the C. utilis cell growth but also indicated the importance of the yeast culture physiological state for resistance to Ca2Fe2O5. To the best of our knowledge, this is the first study that evaluated the fungicidal activity of Ca2Fe2O5 porous powder on C. utilis and the impact of the C. utilis phase of growth on the cell susceptibility. Graphical abstract: [Figure not available: see fulltext.]

Keywords
Antifungal | Ca-Fe oxide | Candida utilis | fungi | Growth kinetics | Yeast
DOI
10.1007/s10534-022-00429-x
Hyperlink
https://link.springer.com/article/10.1007/s10534-022-00429-x

Vihodceva, S., Bankovskis, V., Muter, O., Šutka, A. Ca2Fe2O5 Powder Antifungal Activity to the Candida Utilis Culture upon its Growth. BioMetals, 2022, Vol. 35, No. 5, pp.1133-1143. ISSN 0966-0844. e-ISSN 1572-8773. Available from: doi:10.1007/s10534-022-00429-x

Publication language
English (en)