Palladium-Catalyzed C(sp3)-H Arylation of Pentacyclic Triterpenoids

ISySyCat2023 International Symposium on Synthesis and Catalysis 2023 (ISySyCat 2023): Book of Abstracts 2023
Vladislavs Kroškins, Rihards Lācis, Jevgeņija Lugiņina, Māris Turks

Naturally abundant pentacyclic triterpenoids are significant secondary metabolites which have aroused huge interest by possessing wide range of remarkable biological activities such as antitumor1 antidiabetic2 anti-inflammatory3 and antiviral activities4. Oleanolic, ursolic acids and betulin, are the most recognizable compounds of this branch, which are isolated from various plants. The aim of this work is to obtain novel triterpenoic derivatives by C-H arylation at C(22). For this purpose, precursors bearing picolinic amide directing groups were synthesized (Scheme 1).

Keywords
C-H activation, pentacyclic triterpenoids

Kroškins, V., Lācis, R., Lugiņina, J., Turks, M. Palladium-Catalyzed C(sp3)-H Arylation of Pentacyclic Triterpenoids. In: ISySyCat2023 International Symposium on Synthesis and Catalysis 2023 (ISySyCat 2023): Book of Abstracts, Portugal, Evora, 5-8 September, 2023. Evora: Sociedade Portuguesa de Quimica, 2023, pp.204-204.

Publication language
English (en)