A Study on Chitosan-Coated Liposomes as Potential Delivery Systems

Annual Meeting French Society of Nanomedicine (SFNano 2023): Abstract Book 2023
Arkadij Sobolev, Kārlis Pajuste, Ruslan Muhamedejev, Martins Rucins, Nadiia Pikun, Davis Lacis, Martins Kaukulis, Reinis Putralis, Māra Plotniece, Aiva Plotniece

Encapsulation of drug into liposomes may reduce a number of drawbacks, such as rapid clearance, poor biodistribution, low intracellular absorption, and toxicity that may limit their therapeutic efficacy. Decoration of liposomes with chitosan is one of the methods for improving their physical-chemical and biochemical characteristics. Chitosan’s coating on liposomes is primarily based on electrostatic forces.(3) Previously we established that multifunctional pyridinium derivatives on the 1,4-dihydropyridine (1,4-DHP) core formed liposomes and were found to be active as gene delivery agents. Additionally, the effects of lipid head-groups, linker structure, and cationic moieties’ shift from 1,4-DHP core on transfection activity were also studied.

Keywords
liposome, amphiphile, modified chitosan, coating, delivery

Sobolev, A., Pajuste, K., Muhamedejev, R., Rucins, M., Pikun, N., Lacis, D., Kaukulis, M., Putralis, R., Plotniece, M., Plotniece, A. A Study on Chitosan-Coated Liposomes as Potential Delivery Systems. In: Annual Meeting French Society of Nanomedicine (SFNano 2023): Abstract Book, France, Montpellier, 4-6 December, 2023. Montpellier, Le Corum: 2023, pp.47-47.

Publication language
English (en)