Statement of the problem. It is important to consider the characteristics of the soil base when calculating models of multi-story frame buildings and determining the forces and deformations in their elements. The influence of the foundation is manifested in the redistribution of forces in load-bearing structures and significantly affects the numerical results of the calculation [1]. Today, the requirements for the level of safety of residential buildings have increased, which requires a more complete consideration of the factors that affect the safety of structures. Thus, this study is very relevant. The paper analyzes three variants of models of interaction between a multi-storey frame building and a soil foundation. A modal analysis was performed to evaluate the influence of the soil foundation on the frequencies and eigenvalues of free vibrations of the building. The modeling was performed using the finite element method and implemented in the SCAD software package. The aim of the study is to assess the influence of the soil foundation on the stress-strain state of a multi-story frame building and the eigenvalues and frequencies of its natural vibration forms.