A Copper-Containing Analog of the Biomineral Whitlockite: Dissolution–Precipitation Synthesis, Structural and Biological Properties
Dalton Transactions 2024
Diana Griesiute, Agne Kizalaite, Arita Dubņika, Vytautas Klimavicius, Vidmantas Kalendra, Vaclav Tyrpekl, Sung Hun Cho, Tomoyo Goto, Tohru Sekino, Aleksej Zarkov

In the present work, copper whitlockite (Cu-WH, Ca18Cu2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized, founding the base knowledge for its future studies in medicine, particularly for bone regeneration. This material is a copper-containing analog of the well-known biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis of powders was performed by a dissolution–precipitation method in an aqueous medium under hydrothermal conditions. Phase conversion from brushite (CaHPO4·2H2O) to Cu-WH took place in an acidic medium in the presence of Cu2+ ions. Optimization of the synthesis conditions in terms of medium pH, temperature, time, Ca/Cu molar ratio and concentration of starting materials was performed. The crystal structure of the synthesized products was confirmed by XRD, FTIR and Raman spectroscopy, 1H and 31P solid-state NMR, and EPR. Morphological features and elemental distribution of the synthesized powders were studied by means of SEM/EDX analysis. The ion release in SBF solution was estimated using ICP-OES. Cytotoxicity experiments were performed with MC3T3-E1 cells. The study on thermal stability revealed that the synthesized material is thermally unstable and gradually decomposes upon annealing to Cu-substituted β-Ca3(PO4)2 and Ca2P2O7.


DOI
10.1039/d3dt03756h
Hyperlink
https://pubs.rsc.org/en/content/articlelanding/2024/DT/D3DT03756H

Griesiute, D., Kizalaite, A., Dubņika, A., Klimavicius, V., Kalendra, V., Tyrpekl, V., Hun Cho, S., Goto, T., Sekino, T., Zarkov, A. A Copper-Containing Analog of the Biomineral Whitlockite: Dissolution–Precipitation Synthesis, Structural and Biological Properties. Dalton Transactions, 2024, Vol. 1, No. 1, pp.1-13. ISSN 1477-9234. Available from: doi:10.1039/d3dt03756h

Publication language
English (en)
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