Exploration of Novel 1,2-Dihydropyridine Derivatives: Potential Antimicrobial Agents and Innovative Delivery Platforms
Final Conference “Achievements of SPRINGBOARD Project”: Abstract Book
2024
Davis Lacis,
Nadiia Pikun,
Ernests Tomass Auzins,
Martins Rucins,
Martins Kaukulis,
Reinis Putralis,
Māra Plotniece,
Kārlis Pajuste,
Aiva Plotniece,
Janis Liepins,
Arkadij Sobolevs
Introduction of fluorine or additional lipophilic alkyl substituents into heterocycles may modulate their properties and enhance biological activity. Synthesis of 1,2-DHP and Py derivatives with fluorine atoms or lipophilic moieties; characterization of formed nanoparticles; studies of antibacterial activities and toxicity; evaluation of the structure-activity relationships were performed. Synthesis of compounds was performed using reported methods. Modifications of 1,2-DHP were performed in two ways. Fluorination leads to the fluoro/difluoromethyl substituted derivatives. Quaternization of pyridine moiety with alkyl halides forms cationic compounds with additional alkyl moieties.
Keywords
lipophilic alkyl substituents, 1,2-DHP, nanoparticles,
Lacis, D., Pikun, N., Auzins, E., Rucins, M., Kaukulis, M., Putralis, R., Plotniece, M., Pajuste, K., Plotniece, A., Liepins, J., Sobolevs, A. Exploration of Novel 1,2-Dihydropyridine Derivatives: Potential Antimicrobial Agents and Innovative Delivery Platforms. In: Final Conference “Achievements of SPRINGBOARD Project”: Abstract Book, Latvia, Riga, 2-3 May, 2024. Riga: 2024, pp.P7-P7.
Publication language
English (en)