Low-Temperature Aqueous Synthesis and Biocompatibility of Manganese Whitlockite
Ceramics International 2024
Agne Kizalaite, Arita Dubņika, Andris Antuzevics, Tomas Murauskas, Orlando Stewart Jr., Sarah L. Stoll, Tomoyo Goto, Tohru Sekino, Aleksej Zarkov

In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.


Keywords
Manganese whitlockite, Ca18Mn2(HPO4)2(PO4)12, Dissolution-precipitation, Cell viability
DOI
10.1016/j.ceramint.2024.05.157
Hyperlink
https://www.sciencedirect.com/science/article/pii/S0272884224020170?via%3Dihub

Kizalaite, A., Dubņika, A., Antuzevics, A., Murauskas, T., Stewart Jr., O., L. Stoll, S., Goto, T., Sekino, T., Zarkov, A. Low-Temperature Aqueous Synthesis and Biocompatibility of Manganese Whitlockite. Ceramics International, 2024, Vol. 50, No. 16, pp.28490-28497. ISSN 0272-8842. e-ISSN 1873-3956. Available from: doi:10.1016/j.ceramint.2024.05.157

Publication language
English (en)
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