Synthesis of 3-Benzazepines via Cobalt-Catalyzed C–H Bond Functionalization with CaC2 as the Acetylene Source

Organic Letters 2024
Aleksandrs Čižikovs, paula Amanda Zagorska, Liene Grigorjeva

Herein, we report a simple method for the synthesis of 3-benzazepine derivatives via a cobalt-catalyzed, picolinamide-directed α-amidoacrylate C(sp2)-H bond functionalization approach. The reactions utilize calcium carbide as an inexpensive, easy-to-handle, and solid acetylene source, and simple CoCl2 as the reaction catalyst. Excellent functional group tolerance is observed, yielding diverse substituted 3-benzazepine derivatives in good to excellent yields.

DOI
10.1021/acs.orglett.4c03551
Hyperlink
https://pubs.acs.org/doi/10.1021/acs.orglett.4c03551

Čižikovs, A., Zagorska, P., Grigorjeva, L. Synthesis of 3-Benzazepines via Cobalt-Catalyzed C–H Bond Functionalization with CaC2 as the Acetylene Source. Organic Letters, 2024, Vol. 26, No. 44, pp.9536-9540. ISSN 1523-7060. Available from: doi:10.1021/acs.orglett.4c03551

Publication language
English (en)