Fluorohalomethylsulfonium Salts as a Fluorohalocarbene Source

Organic Letters 2024
Artūrs Sperga, Toms Pfeifers, Dzintars Zacs, Jānis Veliks

Synthesis of fluoroorganic compounds is of great importance due to their extensive application in medicinal chemistry, agrochemicals, and materials. Herein, we report efficient synthesis of novel diaryl fluorohalomethyl sulfonium salts. The application showcased proficient reagents for Freon-free fluorochloro-, fluorobromo-, and fluoroiodocarbene transfer to alkenes. The developed mild, room temperature conditions for the cyclopropanation do not require any metal catalysts and allow synthetic access to diverse cyclopropanes.

Keywords
Carbene compounds, Hydrocarbons, Reactivity, Reagents, Salts
DOI
10.1021/acs.orglett.4c02327
Hyperlink
https://pubs.acs.org/doi/10.1021/acs.orglett.4c02327

Sperga, A., Pfeifers, T., Zacs, D., Veliks, J. Fluorohalomethylsulfonium Salts as a Fluorohalocarbene Source. Organic Letters, 2024, Vol. 26, No. 30, pp.6482-6485. ISSN 1523-7060. Available from: doi:10.1021/acs.orglett.4c02327

Publication language
English (en)