Collagen is a fundamental component of the organic phase of bone, providing the structural framework necessary for mineral deposition and cell-matrix interactions. It plays a key role in bone regeneration by supporting osteoblast attachment, proliferation, and extracellular matrix remodeling. It makes up 89% of the organic matrix and 32% of the volume composition of bones. While collagen can be derived from various sources, marine organisms have gained attention as sustainable and low-immunogenic alternatives. Jellyfish-derived collagen, in particular, is considered a promising biomaterial due to its high biocompatibility and bioactivity. In addition, collagen can be easily integrated with other bioactive materials, improving the mechanical stability and biological activity of composite scaffolds.