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Publikācija: Bioreactor-Free Tissue Engineering: Directed Tissue Assembly by Centrifugal Casting

Publication Type Publication (anonimusly reviewed) in a journal with an international editorial board indexed in other databases
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Bioreactor-Free Tissue Engineering: Directed Tissue Assembly by Centrifugal Casting
Field of research 2. Engineering and technology
Sub-field of research 2.6 Medical engineering
Authors Viktors Mironovs
Vladimirs Kasjanovs
Roger R. Markwald
Glen Prestwich
Keywords tissue engineering, centrifugal casting, in situ cross-linkable hydrogel, synthetic extracellular matrix, hyaluronan
Abstract Casting is a process by which a material is introduced into a mold while it is liquid, allowed to solidify in a pre-defined shape inside the mold, and then removed to give a fabricated object, part, or casing. Centrifugal casting could be defined as a process of molding using centrifugal forces. Although the centrifugal casting technology has a long history in metal manufacturing and in the plastics industry, only recently has this technology attracted the attention of tissue engineers. Initially, centrifugation was used to optimize cell seeding on a solid scaffold. More recently, centrifugal casting has been used to create tubular scaffolds and both tubular and flat multilayered, living tissue constructs. These newer applications were enabled by a new class of biocompatible in situ cross-linkable hydrogels that mimic the extracellular matrix. Herein we summarize the state of the art of centrifugal casting technology in tissue engineering, we outline associated technological challenges, and we discuss the potential future for clinical applications.
DOI: 10.1517/14712598.8.2.143
Reference Mironovs, V., Kasjanovs, V., Markwald, R., Prestwich, G. Bioreactor-Free Tissue Engineering: Directed Tissue Assembly by Centrifugal Casting. Expert Opinion on Biological Therapy, 2008, Vol.8, No.2, pp.143-152. ISSN 1471-2598. e-ISSN 1744-7682. Available from: doi:10.1517/14712598.8.2.143
ID 4932