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Publikācija: Reactogenicity of Synthetic Hydroxyapatite (HAp) Ceramic Materials Implantedin Rabbits Jaws

Publication Type Full-text conference paper published in other conference proceedings
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Reactogenicity of Synthetic Hydroxyapatite (HAp) Ceramic Materials Implantedin Rabbits Jaws
Field of research 3. Medical and Health sciences
Sub-field of research 3.1 Basic medicine including pharmacy
Authors Līga Bērziņa-Cimdiņa
Māra Pilmane
Andrejs Skaģers
Ilze Šalma
Ģirts Šalms
Jānis Vētra
Keywords hydroxyapatite ceramic, reactogenicity, growth factors, apoptosis
Abstract Experimental comparing of morphofunctional changes in implant contact tissue with same tissue involved in surgical intervention of same manner without insertion of artificial materials can clarify specific reactogenicity of implant and/or material. To evaluate early reactogenicity of porous synthetic HAp ceramic implants inserted in holes of rabbit upper jaw assessment of inflammatory response and regeneration in contact bone and soft tissue using histological and immunohistochemical methods was done. Our results demonstrated stimulation of TGFß and FGFR1 in bone after HAp implantation indicating possible osseoinductive role for the same Hap implants. Also moderate apoptosis and rich expression of FGFR1 in connective tissue around HAp implants commonly indicated intensive regeneration ability of the soft tissue with such cell death type that does not cause the fibrotic changes. Neuropeptide-containing innervation was not involved in healing processes after HAp implantation.
DOI: 10.1007/978-3-540-69367-3_20
Reference Bērziņa-Cimdiņa, L., pilmane, M., Skaģers, A., Šalma, I., Šalms, Ģ., Vētra, J. Reactogenicity of Synthetic Hydroxyapatite (HAp) Ceramic Materials Implantedin Rabbits Jaws. In: 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics: IFMBE Proceedings. Vol.20, Latvia, Rīga, 16-20 June, 2008. Berlin: Springer Berlin Heidelberg, 2008, pp.72-75. ISBN 978-3-540-69366-6. e-ISBN 978-3-540-69367-3. ISSN 1680-0737. Available from: doi:10.1007/978-3-540-69367-3_20
ID 4985