Synthesis of Triazole-Functionalized Tetrahydroindazolones by 1,3-dipolar Cycloadditions between Azides and Alkynes

Tetrahedron Letters 2009
Inta Strakova, Māris Turks, Andris Strakovs

7-Azido-tetrahydroindazolones undergo efficient copper-catalyzed Huisgen 1,3-dipolar cycloaddition reactions with various alkynes leading to a straightforward synthesis of triazole-functionalized tetrahydroindazolones. The latter are interesting molecular platforms in terms of medicinal chemistry.

Keywords
tetrahydroindazolones, azides, triazoles, Huisgen 1,3-dipolar cycloaddition
DOI
10.1016/j.tetlet.2009.04.009
Hyperlink
http://www.sciencedirect.com/science/article/pii/S0040403909008107

Strakova, I., Turks, M., Strakovs, A. Synthesis of Triazole-Functionalized Tetrahydroindazolones by 1,3-dipolar Cycloadditions between Azides and Alkynes. Tetrahedron Letters, 2009, Vol.50, Iss.25, pp.3046-3049. ISSN 0040-4039. Available from: doi:10.1016/j.tetlet.2009.04.009

Publication language
English (en)