RTU Research Information System
Latviešu English

Publikācija: Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole Scaffold

Publication Type Scientific article indexed in ERIH database, in INT1 or INT2 category journals
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole Scaffold
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Marina Teus
Aigars Jirgensons
Maija Dambrova
Rudolfs Mezapuke
Chris Graham Parsons
Wojciech Danysz
Keywords glutamate carboxypeptidase II, glutamate, 5-hydroxyisoxazole, lipophilicity, synthesis
Abstract Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.
DOI: 10.2174/157018009787158544
Reference Teus, M., Jirgensons, A., Dambrova, M., Mezapuke, R., Parsons, C., Danysz, W. Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole Scaffold. Letters in Drug Design & Discovery, 2009, Vol.6, No.1, pp.29-32. ISSN 1570-1808. Available from: doi:10.2174/157018009787158544
ID 6521