A systematic electrochemical investigation is performed to study the effect of polyvinylidene difluoride (PVDF) based polymer binders on the performance of different cathodes for lithium-ion batteries in ionic liquid (IL) based electrolytes. Electrochemical tests indicate that the nature of PVDF effects significantly on cathode stability in IL based electrolytes. The copolymer such as hexafluoropropylene (HFP) plays a significant role in the interfacial resistance. Application of PVDF-HFP binder leads to more cohesive particle network that result in reducing capacity fading of cathodes during the battery cycling.