The human body functions most effective in the definite environmental temperature range. High heat conditions may cause health problems. The smart clothes with integrated cooling system is one of the smart textiles solution to microclimate regulation of humans body. By the manufacturing of smart clothes with integrated microclimate control system, that operates with energy produced of solar cells, researches for optimization of cooling function are carried out. In the experiments with thermobattery and the different thickness of copper, bronze and steel threads and different density fabrics, as well as copper foil, it is observed, that the copper foil provides the necessary heat removal, which, in turn, provides favorable conditions for the cooling.