Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV
Dace Rasiņa,
M. Otikovs,
J. Leitans,
R. Recacha,
O. Borysov,
I. Kanepe-Lapsa,
I. Domraceva,
T. Pantelejevs,
K. Tars,
M. Blackman,
Kristaps Jaudzems,
Aigars Jirgensons
Representative spectra from NMR based fragment screening; X-ray structure descriptors, description of synthesis for amines 7b–g and pinacolborates 13a–d,f–l
Date
15.12.2015.
Keywords
Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV
DOI
10.1021/acs.jmedchem.5b01558
Hyperlink
https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.5b01558