Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides
XX International Roundtable on Nucleosides Nucleotides and Nucleic Acids: Poster Abstracts
2012
Irina Novosjolova,
Armands Kovaļovs,
Inga Bižāne,
Ērika Bizdēna,
Māris Turks
A novel class of ditriazolylpurine nucleosides were ob-tained from 2,6-diazido precursors via copper catalyzed azide-alkyne cycloaddition. These intermediates ap-peared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. The latter products exhibit interesting fluorescence properties.
Keywords
ditriazolylpurine nucleosides, 1,3-dipolar cycloaddition reaction, fluorescence
Hyperlink
http://www.is3na.org/assets/events/Category%203-Nucleos%28t%29ide%20Probes%20%28109-153%29.pdf#page=26
Novosjolova, I., Kovaļovs, A., Bižāne, I., Bizdēna, Ē., Turks, M. Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides. In: XX International Roundtable on Nucleosides Nucleotides and Nucleic Acids: Poster Abstracts, Canada, Montreal, 5-9 August, 2012. [S.l.]: IS3NA, 2012, pp.134-134.
Publication language
English (en)