Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides

Synthesis 2012
Tatjana Kukoša, Nadežda Trjufilkina, Sergejs Beļakovs, Mārtiņš Katkevičs

The synthesis of N-aryl-O-alkyl hydroxamic acid derivatives by copper-catalyzed cross-coupling of hydroxamates and aryl iodides is described. The reaction conditions are compatible with standard hydroxyl protecting groups on the hydroxylamine moiety and are applicable to a broad range of coupling partners.

Keywords
copper, aArylation, cross-coupling, hydroxamates, aryl iodides
DOI
10.1055/s-0031-1290384
Hyperlink
https://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1290384

Kukoša, T., Trjufilkina, N., Beļakovs, S., Katkevičs, M. Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides. Synthesis, 2012, Vol.44, Iss.15, pp.2413-2423. ISSN 0039-7881. Available from: doi:10.1055/s-0031-1290384

Publication language
English (en)