Regioselective Nucleophilic Aromatic Substitution of 2,6-Bis-(1,2,3-Triazolyl)-Purine Derivatives with Various Nucleophiles

Proceedings of 14th Tetrahedron Symposium "Challenges in Organic and Bioorganic Chemistry" 2013
Irina Novosjolova, Ērika Bizdēna, Māris Turks

A novel class of bis-triazolyl purine nucleosides were obtained from 2,6-diazido precursors via copper (I) catalyzed azide-alkyne cycloaddition. These intermediates appeared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. The obtained 2-triazolyl purine derivatives exhibit interesting fluorescence properties.

Keywords
Purine nucleosides, bis-triazolyl derivatives, fluorescence

Novosjolova, I., Bizdēna, Ē., Turks, M. Regioselective Nucleophilic Aromatic Substitution of 2,6-Bis-(1,2,3-Triazolyl)-Purine Derivatives with Various Nucleophiles. In: Proceedings of 14th Tetrahedron Symposium "Challenges in Organic and Bioorganic Chemistry", Austria, Vienna, 25-28 June, 2013. Vienna: Elsevier Ltd., 2013, pp.147-147.

Publication language
English (en)