Reactivity Studies of 2,6-Bis-(1,2,3-triazolyl)purine Nucleosides with Hydrazines and Amino Acids

Proceedings of XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids 2014
Edgars Laķis, Irina Novosjolova, Ērika Bizdēna, Māris Turks

Reactions of 2,6-bis-(1,2,3-triazolyl)purine nucleosides with nucleophiles is efficient route to C(6)-derivatization of purine base. To extend the field of application of the method, we studied reactivity of bis-(1,2,3-triazolyl)purine derivatives toward hydrazines and amino acids and obtained nucleosides substituted at C(6) with hydrazine and amino acid moieties.

Keywords
bis-triazolyl derivatives, purine nucleosides, hydrazines

Laķis, E., Novosjolova, I., Bizdēna, Ē., Turks, M. Reactivity Studies of 2,6-Bis-(1,2,3-triazolyl)purine Nucleosides with Hydrazines and Amino Acids. In: Proceedings of XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids, Poland, Poznań, 24-28 August, 2014. Poznań: 2014, pp.32-32.

Publication language
English (en)