This Paper is a review within a number of the planned articles devoted to finding out and determining a range of scientific activity of the Republic of Latvia on a global scale of nanotechnologies. Purpose of the current Paper is to provide a review on the legal fundamentals in creating a local scientific environment for development of the advanced technologies in Latvia. The main methods applied by the authors are analysis of the scientific and professional literature and official documentation, and logical approach. A focus on the local documentation through integration into the European Union is accepted limitation of the Paper. The main findings ensuring the value of the Paper are: Latvia is not named among the priority regions in the newest EU’s smart specialisation platform. Despite for the nearest years the nanotechnologies are announced in the second priority for the Latvian science development, an international collaboration of Latvia is at very high rate - 70% on average and 77% of the investment volume to the scientific projects is assigned from the EU, limitations in local tooling and professionalism are obvious, it cause currently our country is still at the foundation stage.