Triazolylpurine Nucleosides: Synthetic Approaches and Biological Activity

Proceedings of 16th Florida Heterocyclic and Synthetic Conference 2015
Irina Novosjolova, Ērika Bizdēna, Pieter Leyssen, Johan Neyts, Māris Turks

A novel method for the synthesis of C(2) and C(6) modified purine nucleoside analogues has been developed. The obtained triazolyl purine nucleosides were tested for their activity against Chikungunya virus, murine Norovirus, enterovirus 71 and yellow fever virus. Their cytotoxicity also was examined.

Keywords
purine nucleosides, bis-triazolyl derivatives, triazolyl purine nucleosides

Novosjolova, I., Bizdēna, Ē., Leyssen, P., Neyts, J., Turks, M. Triazolylpurine Nucleosides: Synthetic Approaches and Biological Activity. In: Proceedings of 16th Florida Heterocyclic and Synthetic Conference, United States of America, Gainesville, 1-4 March, 2015. Gainesville: 2015, pp.180-180.

Publication language
English (en)